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In both cases the distinction is important

Mechanism of action: GLP-1 receptor agonists bind to GLP-1 receptors located throughout the body, particularly in pancreatic beta cells, the gastrointestinal tract, and the central nervous system

Individuals with severe heart failure (NYHA Class IV) were largely excluded from major clinical trials, meaning safety data in this population remain limited

Members existing authorizations for Humira/Stelara will end December 31, 2025, with new biosimilar authorizations already in place for one year

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