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Gastro-intestinal symptoms score was assessed based on the score of Adam and collaborators 16 as follows: Parents were asked to indicate whether their children had experienced specific GI symptoms nausea, vomiting, bloating, abdominal cramps, early satiety, eructation or heartburn, loss of appetite, retrosternal discomfort and epigastric pain or abdominal pain over the past month

Lotte Bjerre Knudsen (30:46): We are in the process of trying to see if we could take those signatures and apply them on to our data

The incidence of headaches does not appear to increase with higher doses, though individual responses vary significantly