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Signalling pathways studied in preclinical models illustrative Growth Hormone Secretagogue GHRH-R Agonism Tesamorelin is a synthetic trans-3-hexenoic acidmodified analog of human GHRH(1-44)

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The large molecular size of GLP-1 peptides makes transdermal delivery highly implausible without advanced technology not present in consumer products

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The anti-inflammatory and antioxidant effects of GLP-1RAs observed in other organ systems may prevent damage in ocular tissues, leading to reduced risk of nonexudative age-related macular degeneration (AMD), exudative AMD, and primary open-angle glaucoma (POAG) compared to other diabetic medications (Figure 1)

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