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Hippo signaling regulates YAP primarily through large tumor suppressor kinases 1 and 2 (LATS 1/2), which are activated through phosphorylation by mammalian sterile 20-like protein kinases 1/2 (MST1/2)

Regarding tirzepatide specifically, the SURPASS clinical trial program, which enrolled over 10,000 participants, did not identify memory impairment or cognitive decline as a significant adverse event