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10.1182/blood-2020-137266 170 ScaliseM.PappacodaG.MazzaT.ConsoleL.PochiniL.IndiveriC

Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes

It validates years of advocacy by clinical organizations arguing that compounding restrictions should be proportional to actual patient risk not applied uniformly across categories

Morais M, Machado V, Figueiredo P, et al

Interaction of reactive oxygen species with ion transport mechanisms

Western blot analysis revealed decreased expression of ferroptotic modulator glutathione peroxidase 4 (GPX4)