Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances (Chang et al., 2007)
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Notably, Gln deprivation significantly reduced the expression of CCNB1, CDK1 and p-CDK1 in HCC and PCa cells (Fig