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It turns out that the idea of tirzepatide producing more significant weight loss than semaglutide in patients with type 2 diabetes isnt new, as demonstrated in a New England Journal of Medicine article reporting clinical data for tirzepatide versus semaglutide once weekly in patients with type 2 diabetes

US President Donald Trump in November announced deals with Novo Nordisk as well as Eli Lilly to lower the prices of some of their weight-loss drugs in exchange for certainty around tariffs

Future Directions and Research Opportunities Triple Agonism and Beyond The success of dual agonism has stimulated interest in triple agonism approaches that add glucagon receptor activation to GIP and GLP-1 targeting

In real world practice, we lack markers to determine which patients will develop advanced AKI and disease progression to severe outcomes

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doi: 10.1016/j.bcp.2018.06.003 110 ShubinaVSKozinaVIShatalinYV