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Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

In Table 2, we evaluated the number of first-time NAION events, person-years at risk, incidence rates, and we performed a crude and a multivariable Cox proportional hazard regression adjusted for sex, age, marital status, duration of diabetes, hemoglobin A1c, estimated glomerular filtration rate, history of cardiovascular disease, use of insulin, use of cholesterol lowering medicine, and use of blood pressure lowering medicine

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Both groups are making mistakes, just in opposite directions

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Early in life, these responses help maintain cellular stability, but persistent activation over time can contribute to pathology