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GLP-1 inhibits intestinal contractions through mechanisms that may involve the central nervous system via vagal pathways or direct action on central receptors [24], as well as the enteric nervous system by modulating neurotransmission through presynaptic receptors affecting nitric oxide release [25,26]

What the pharmacokinetic research shows Eli Lilly published a Phase 1 study specifically examining tirzepatide absorption across all three injection sites

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Sen S, Potnuru PP, Hernandez N, Goehl C, Praestholm C, Sridhar S, et al

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