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The MHRA-approved indication specifies use alongside diet and exercise for type 2 diabetes only (not type 1 diabetes or diabetic ketoacidosis), and the medication is administered once weekly via subcutaneous injection, providing sustained therapeutic levels throughout the dosing interval

Variants in the GLP1R gene (particularly rs6923761), GIPR pathway genes, and FTO gene expression affect both appetite suppression intensity and metabolic rate

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