mushrooms a rich source of the antioxidants ergothioneine and glutathione for cognitive health, longevity healthy ageing: where are we now? | Proceedings Nutrition Society Ergothioneine in Mushrooms: Health Effects

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Reported benefits (per available research): Studied for restoring more youthful pulsatile GH and IGF-1 secretion in older adults, based on a small 1997 randomized, placebo-controlled human trial of a closely related GHRH(1-29) analog published in the Journal of Clinical Endocrinology & Metabolism May support gains in lean body mass in men specifically: that same 16-week trial found a statistically significant increase in lean body mass in men but not in women, alongside a significant increase in skin thickness (a marker of dermal collagen) in both sexes Proposed to support broader recovery and body-composition goals tied to growth-hormone-axis activity, though sermorelin-specific modern adult trial data remains thin, and much of the anti-aging and muscle-building framing used in commercial marketing outpaces the current clinical evidence base Known risks and side effects: Injection-site reactions (pain, swelling, or redness) are the most commonly reported adverse event associated with sermorelin therapy in manufacturer drug-labeling data Headache, flushing, dizziness, difficulty swallowing, hyperactivity, drowsiness, and hives have also been reported less commonly per that same labeling data

doi: 10.1016/j.cell.2019.05.012 81 Hernndez-CamareroPLpez-RuizEMarchalJAPernM

Getting the angle right is key to making sure the B12 is delivered correctly and the injection is as comfortable as possible

Meanwhile, Glutathione helps reduce oxidative stress, which helps to protect and preserve NAD+

[194] Richardson GM, Brecher RW, Scobie H, Hamblen J, Samuelian J, Smith C