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40 In particular, [Pro 9 ]-GLP-1 showed a remarkable capability of moderating plasma glucose excursion and enhancing the circulating insulin level in severely insulin-resistant obese diabetic mice

Stumpfe et al., 2012

Yes, patients start losing weight even with the starting dose of 0.25 mg

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Association between Glucagon-Like Peptide 1 (GLP-1) Receptor Agonists Exposure and Intraocular Pressure Change

Adults who have a BMI of 27 or higher and also have at least one weight-related health condition, such as type 2 diabetes, high blood pressure, high cholesterol, or sleep apnea