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Higher expectations - Mounjaro at its highest dose (15mg) produces an average weight loss of 22.5% of body weight at 72 weeks, compared to 20.7% for Wegovy at its highest dose

In view of the balance regulation of GSH and ROS levels in tumor cells, GSH depletion may indirectly induce cell pyroptosis, but it has not been reported yet

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Intermittent or reduced-dose strategies lack robust clinical trial support and may result in partial benefit loss

The dual-action setup might explain why it has been pulling ahead in some studies

Some injectable GLP-1 receptor agonists (liraglutide, dulaglutide, and subcutaneous semaglutide) have demonstrated cardiovascular benefits in high-risk patients in clinical trials