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Given the promising data from this study, Neurogastrx is looking to launch a larger Phase 2 study in 2025

S6 show that both GLP-1RA and SGLT-2 inhibitors were associated with a lower risk (13% and 14%, respectively) as compared with placebo and DPP-4 inhibitors (11% and 12%, respectively), although the difference in risks was significant for SGLT-2 vs DPP-4 inhibitors only

To test whether any of these exopolymers constitutes AEP, deletion mutants for each exopolymer, as well as a triple mutant defective for all three polymers, were tested for their ability to secrete AEP

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In contrast, studies of GLP-1RAs directed specifically at understanding their impact in pulmonary diseases in patients without obesity or T2DM remain limited