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However, folate or methyfolate supplementation in certain SZ genotype may ameliorate the negative symptoms, which may be reflect reverse changes of hypomethylation of the MB-COMT promoter that resulted from decreased SAMe levels or a reduced ratio of SAM/SAH in variants in folate-related enzymes

IGF-1 levels increased in line with elevated GH

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A no-template control reaction was included for each gene examined

The cost difference reflects the molecular complexity, the FDA approval status, and the consistency of clinical effect