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Its worth noting that AOD-9604 was very well tolerated in trials, with no major safety issues reported

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Abbreviations ATP: Adenosinetriphosphate CADD: Computer aided drug design CDI: Carbonyldiimidazole DIPEA: N, N-diisopropylethylamine DMF: Dimethylformamide GDP: Guanosinediphosphate GN: Guanosine nucleotide GppNHp: Guanosine-5-[(,)-imido]triphosphate GST: Glutathione-S-transferase GTP: Guanosinetriphosphate KRAS: Kirsten rat sarcoma MD: Molecular dynamics MS: Mass spectrometry RBD: Ras binding domain SOS: Son of sevenless SWIIP: Switch-II-pocket References Scheffzek, K

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The specific mechanisms by which ferroptosis contributes to CHD pathophysiology require further elucidation, particularly regarding its interrelationship with other cell death pathways (e.g., apoptosis, necrosis)