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In the AMY 1 R and AMY 3 R Y37 rAmy interacts with residues in the respective RAMP and the CTR ECD, however the small side chain of P37 Cagri is completely buried by the surrounding CTR ECD residues, forming extensive hydrophobic contacts with W79 ECD and no direct interactions with either RAMP1 (AMY 1 R) or RAMP3 (AMY 3 R), again consistent with the restrictive interactions formed by Pro32 sCT with the CTR ECD

Allergic reactions to proprietary preparations of vitamin B12 might be due to substances added to the solutions as preservatives or for other reasons, to impurities from the production, or to the vitamin B12 itself

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