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No clinically relevant changes were observed for laboratory parameters or physical examination

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For weight management, the maximum approved dose is 2.4 mg weekly (Wegovy)

While these guidelines are informed by the surmounting evidence of MACE reduction in the primary preventative cohort at risk of ASCVD [26], the present study adds to the current evidence by providing an in-depth assessment of clinical impact, in terms of the NNT, efficacy and safety of GLP-1RA on MI risk and the individual constituents of ASCVD risk reduction