Manufacturer: Amgen (NASDAQ: AMGN)
Retatrutide activates three receptors, GLP-1, GIP, and glucagon
Proprietary Innovation: By bringing this patented technology in-house, Hims moves beyond just being a service provider to owning a unique hardware advantage in the health-tech space
The FDA has approved Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide) for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, when used with a reduced-calorie diet and increased physical activity
It is not the first-choice injectable for uncomplicated Type 2 diabetes anymore, and understanding this shift helps explain why the GLP-1 question comes up so often
As pharmacological studies highlight the hindbrain nucleus tractus solitarius (NTS) as a brain region important for GLP-1R-mediated effects on energy balance, AAV-GLP-1R was injected into the NTS to examine the role of endogenous NTS GLP-1R signaling in energy balance control