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Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus

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Arizona gila monster, from whose venom exendin-4 was isolated, interacting with human GLP-1 receptors Exendin-4 became the basis for the creation of the first synthetic GLP-1 analogue, exenatide, which was approved in 2005 for the treatment of type 2 diabetes mellitus