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Evidence supporting combined therapy is emerging but remains limited as a recent meta-analysis of randomized controlled trials reported lower risk of HF hospitalization with concomitant SGLT2 inhibitor and GLP-1 receptor agonist therapy compared with monotherapy or standard care [24]

These findings highlight the potential clinical importance of achieving and maintaining weight loss after GLP-1-based treatment initiation. Meeting: European Congress on Obesity 2026 (ECO2026) Never miss a breakthrough: Join the SciTechDaily newsletter

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Potential side effects include: Water retention (especially early in the protocol) Mild joint discomfort or stiffness Temporary fatigue or lethargy Flushing or warmth at the injection site Headaches (typically mild and transient) Most side effects are dose-dependent and resolve with dosage adjustment

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12 In vitro studies have shown that liraglutide, a GLP-1RA, can increase keratinocyte migration