my semaglutide is not working Why GLP-1 medication working? 7 Reasons You’re NOT Losing

Known hypersensitivity : Patients with a history of serious allergic reactions to semaglutide or any of its components should avoid it

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts

P., Schultz G

Nature 2011;481:380-4

The SURMOUNT-1 trial published in the New England Journal of Medicine (Jastreboff et al., 2022) showed average weight loss of 20.9 percent of body weight at the highest tirzepatide dose over 72 weeks

More serious but less common risks include pancreatitis, gallbladder disease, and in people with type 2 diabetes potential worsening of diabetic retinopathy