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Keywords: peptide, immune tolerance, lupus, regulatory T cells, immunotherapy, cytokine, chemokine Introduction Autoimmune rheumatic diseases carry a significant burden of morbidity and mortality and have a substantial economic impact on both individuals and the society as a whole

without it, only 1% of dietary B12 is absorbed through passive diffusion

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At the same time, there is evidence of T cell exhaustion and reduced natural killer cell function, suggesting the immune system is simultaneously overactivated in some pathways and depleted in others

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