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Activation of Y1R results in osteoclast formation, negatively impacting bone maintenance, while activation of Y2R influences bone remodeling by modulating the activity of the sympathetic nervous system

Metabolic changes in tamoxifen-resistant MCF-7 cell lines were manifested with the increase of glutathione, xanthine, and other metabolites involved in antioxidant pathways along with their dysfunctional genes' expression

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On the other hand, it has also been suggested that pancreatic-derived GLP-1 may play a role even under normal circumstances

doi: 10.1053/snep.2001.26794 63 ImigJDRyanMJ