After washing with TBST, the immune complexes were detected via chemiluminescence (Beyotime, Shanghai, China) using a Pierce western blotting kit (Thermo Fisher Scientific)
All these changes, particularly in the first few weeks of treatment or in the early days of dose adjustment, can leave the body feeling drained while the body adapts
More importantly, a large-scale 3b-phase randomized controlled trial (SURMOUNT-5), which compared semaglutide with tirzepatide in 751 obese adults without type 2 diabetes, explicitly reported that male patients had an average weight loss approximately 6 percentage points lower than female patients after 72 weeks of semaglutide treatment, further verifying that sex is an independent factor affecting semaglutides efficacy [80]
This makes it challenging to determine whether joint pain is a medication side effect or related to underlying health conditions
This is a humongous red flag, and very scary to me, obesity physician Scott Kahan told Katie
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