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Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice

Without automatic substitution authority, the biosimilar company must deploy a commercial team equivalent in scale to a branded drug launch to specifically drive prescribers toward its product a cost structure that fundamentally undermines the low-price, high-volume generic business model

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The data show that a substantial number of Phase II awards are attracting Phase III funding, although the figure does not make clear the substantial lags involvedPhase II awards are often ripe for Phase III 4 or more years after the award