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While therapeutic drug monitoring (TDM) is essential to prevent underexposure associated with increased rejection risk, and overexposure, which leads to an increase in adverse events, it has limitations in predicting the required Tac dose, due to the many factors that impact the Tac metabolism (12)

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92,139 Genomic DNA methylation levels were significantly decreased in the DPN group compared with the non-DPN group when the duration is 5 years

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