Treatment and monitoring of SAGE-DM Currently, there is no specific evidence-based treatment algorithm for SAGE-DM However, the management of SAGE-DM should be adapted from geriatric diabetes guidelines, considering the underlying aging mechanisms that may affect the response to treatment The following recommendations can thus be viewed as an adaptation of standard care within the SAGE-DM conceptual framework rather than a fully validated treatment pathway Monitoring HbA1c may be unreliable in in the elderly due to comorbidities affecting red blood cell lifespan (e.g., advanced kidney disease, GI bleeding, heart valve defects)
Histamine and saline were used as positive and negative controls, respectively
This involves administering the peptide as close as safely possible to the actual injury
& Li, D
The 2025 narrative review noted that despite the volume of preclinical work, well-controlled human trial data are scarce, and the regenerative findings should be interpreted accordingly (PMID 40789979)
Vitamin B12 is one of the nutrients your body needs to keep your nerve and blood cells healthy
