who should not use glp 1 Are YOU a Slow/Non-Responder to GLP-1's? Understanding the Risks of GLP-1

For many people on their weight loss journeys, semaglutide is a highly effective treatment when it comes to weight loss, especially for those struggling with obesity or related health issues

Dysregulation of ERAD can lead to the accumulation of misfolded proteins, chronic ER stress, and ultimately, cardiac dysfunction

However, using a five-year federal model, the Centers for Medicare & Medicaid Services will negotiate pricing and coverage terms on GLP-1s for Medicare Part D plans and participating state Medicaid agencies beginning in 2027

GLP-1RAs, such as liraglutide, inhibit the PINK1/Parkin pathway and restrain excessive mitophagy, protecting RGCs from a high glucose environment

(3) There is no interventional calorie or energy restriction

doi: 10.1186/s13059-024-03325-4 79 ZhongJRaoXRajagopalanS