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In summary, we conclude that the glutathione system is the dominant mediator of antioxidative electron flux under pronounced pro-oxidative conditions across different eukaryotic kingdoms

Consistent with our microarray data, we found a significant increase in the expression of Fasn , which encodes fatty acid synthetase, and Ppara , which encodes PPAR, the master transcriptional regulator for -oxidation, in adipocytes lacking GPR146 (Fig

Platt D, Griggs RC

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Once regenerated, glutathione can continue to combat free radicals , which are yielded by both environmental and lifestyle factors including the consumption of alcohol, processed foods, exposure to pollution, chemicals, and even sunshine

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