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10.1080/03602532.2017.1306544 Drug Metab Rev

All three published full-paper human studies include Edwin Lee as lead author

In in vitro studies, transient exposure of human esophageal squamous epithelial cells to acidic bile salt solution did not result in epithelial cell necrosis, but rather promoted cellular secretion of IL-8 and IL-1, which induced recruitment of lymphocytes and neutrophils further leading to epithelial cell necrosis (66)

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Maintain neutral pH during reconstitution and use to preserve complex integrity