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The International Federation of Gynecology and Obstetrics (FIGO) staging remains the single most important prognostic factor: five-year relative survival approaches 92% when disease is confined to the ovaries (stage I) but falls to 32% with distant metastasis (stage IV) [46, 47]

This restriction is in place because methylene blue is a potent drug with significant physiological effects and risks (like serious drug interactions and contraindications), so its use must be professionally supervised

Without adequate copper, collagen formation produces weak, unstable structures