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Through multiple pathways, amino acid metabolism determines the direction of macrophage polarization in MS, and together these mechanisms highlight the dual role of amino acid metabolism in MS pathogenesis and as a therapeutic target

HO-1 Antioxidant and Cytoprotective Pathway BPC-157 activates haem oxygenase-1 (HO-1), a key intracellular antioxidant and cytoprotective enzyme, which modulates oxidative stress, reduces lipid peroxidation, and protects cells from HNE (4-hydroxynonenal)-mediated growth inhibition

5.5 The effects of PCs on atypical complications of diabetes 5.5.1 PCs and diabetic encephalopathy Diabetic encephalopathy (DE), a diabetes-related complication marked by central nervous system damage, primarily results from cerebral microangiopathy, including conditions such as stroke, dementia, and depression (van Sloten et al., 2020)

Previous studies have clarified the effects of metformin on the GLUTs family [43] and simvastatin [44] on the SREBP2 family

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