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This washout period allows sympathomimetic effects to clear and prevents acute cardiovascular strain during the transition phase

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Huehls AM, Coupet TA, Sentman CL

However, not all patients require or benefit from 15 mgsome achieve excellent results at 10 mg or 12.5 mg, which is why personalized assessment matters

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Immunoglobulin-A levels and expression of antimicrobial peptides are gastrointestinal markers that provide insight into gut immunity and potential etiology of gut-centric disease processes 31