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Potential contribution of hypoxia-inducible factor-1, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage

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The most common adverse events are gastrointestinal in nature, including nausea (20-47% depending on dose), constipation (21%), fatigue (20%), and vomiting (8%)

F., Thurman, D

Rybelsus is designed to be taken on an empty stomach in the morning with no more than 4 oz of plain water