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In women, this may lead to a feeling of fullness or a modest increase in breast size, although this is not a universal side effect and is typically mild. She adds that, in most cases, any breast enlargement associated with spironolactone improves or resolves once the medication is discontinued

American Society of Hematology, 1998

Moreover, they obtained a decrease in average HbA1c of up to 2.2 percentage points

therefore, for this reason it was not used as a target for diabetic therapy, unlike GLP-1