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Dwyer et al

If nausea or vomiting is severe or persistent, or if there are signs of dehydration (e.g., reduced urine output, dizziness, dry mouth), patients should contact their GP or diabetes specialist nurse promptly

GLP-1 receptors exist on cardiac tissues, and flooding these receptors with high drug concentration disrupts normal heart rhythm regulation

Different from HbA1c, in terms of weight loss, other GLP-1RAs had better weight loss effect except PEX168 100ug [0.49 kg (95% CI: 0.47, 1.46 kg)] was not as effective as placebo

Patients with genetic variants associated with stronger GLP-1R pathway response may reach effective doses more quickly, while those with variants suggesting lower receptor sensitivity may benefit from higher target doses or complementary compound options

Incubation times and temperatures should be optimized for maximum binding efficiency and stability