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The product of the pyruvate dehydrogenase complex, acetyl-CoA, is a powerful activator of pyruvate carboxylase 168 , the product of which is oxaloacetate

Therefore, exploring safe and effective therapeutic targets is of utmost importance

At the same time, the activities of SOD, glutathione S-transferase, GSH, total mercaptan (TT), CAT, and cholinesterase were decreased, which induced oxidative stress leading to liver cell damage, causing the increase of aspartate aminotransferase and alanine aminotransferase [79]

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Table 1 Inhibitors of ferroptosis and their mechanisms

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