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For each analysis, the statistical test used and n for each group are found in Supplemental Tables 2, 3, or 5

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Supplementary material The Supplementary Material for this article can be found online at: Glossary BA bile acid CYP7A1 cholesterol 7-hydroxylase CYP27A1 sterol-27-hydroxylase CDCA Chenodeoxycholic acid CA Cholic acid CYP8B1 sterol 12-hydroxylase MCAs muricholic acids LCA ithocholic acid DCA deoxycholic acid HCA hyocholicacid HDCA hyodeoxycholic acid IBAT ileal bile acid transporter TCM Traditional Chinese medicine MCD methionine-and choline-deficient CMC-Na carboxymethyl cellulose sodium H&E hematoxylineosin ORO Oil Red O ALT alanine aminotransferase AST aspartate aminotransferase TNF- tumor necrosis factor-alpha TG triglyceride TC total cholesterol RT-qPCR Real-time quantitative PCR PCoA principal coordinates analysis OST organic solute transporter subunit MRP2 Multidrug Resistanceassociated Protein 2 MRP3 Multidrug Resistanceassociated Protein 3 NF-kB nuclear factor-kappaB IL-1 Interlukin-1 beta F/B Firmicutes/Bacteroidetes ASBT apical sodium-dependent bile acid transporter SLC10A2 Solute Carrier Family 10 Member 2 References 1 AnsteeQ