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Orlistat, phentermine/topiramate, naltrexone/bupropion, and the incretin-based drugs liraglutide and semaglutide, both GLP-1 receptor agonists (GLP-1RA), and tirzepatide, a biased dual GIP/GLP-1 receptor agonist, are currently both FDA and EMA approved for the management of non-syndromic obesity 10

All GLP-1RAs have been found to cross the bloodbrain barrier (BBB) and stimulate GLP-1 receptors in the brain, thus offering neuroprotection [17]

Therefore, early diagnosis and detection of MTC are very important for prognosis [3]

Originally a Chinese military fort, it became an enclave after the New Territories were leased to Britain in 1898

doi: 10.4132/jptm.2017.01.04

One week prior to the study, they were acclimatized to the thermal conditions and the animal laboratory facilities