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This includes integrating the latest clinical trial data and delving into potential signaling pathways and pharmacological mechanisms

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We assume each is Michaelis-Menten and take the K m values from[16]

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In head-to-head trials, metformin has been shown to produce equivalent reductions in A1c as sulfonylureas and thiazolidinediones but is more potent than DPP-4 inhibitors (53)