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Cell studies reported reduced 1-methylnicotinamide, altered NAD measurements and reduced lipid accumulation

While elevated MMA blood concentration is considered the specific indicator of deficiency (19), other clinical assays are often used as biomarkers of vitamin B 12 status sometimes in combination

If methotrexate plus glucocorticoid is insufficient, any bDMARDs or tsDMARDs can be recommended to add to csDMARDs, such as methotrexate plus tocilizumab, methotrexate plus rituximab, methotrexate plus tofacitinib, and so on (15)

Nikolaidis, L

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