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Published data (STEP 4, JAMA 2022) show that most patients regain a portion of lost weight after discontinuation

Ann Family Med 10(1):1522 Rubin RR (2005) Adherence to pharmacologic therapy in patients with type 2 diabetes mellitus

doi: 10.1016/j.metabol.2016.04.004 187 GastaldelliACusiK

GLP-1 receptor in pancreatic -cells regulates glucagon secretion in a glucose-dependent bidirectional manner

Mast cell stabilizer: GLP-1 receptors are also found on mast cells, and recent studies have shown that GLP-1 RA drugs prevent overactive mast cell degranulation

People who combine GLP-1 medications with other weight management compounds should be especially careful about frequency and timing