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The Food and Drug Administration (FDA) warns that severe dehydration from GLP-1 drugs may raise the risk of kidney injury and damage

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One important feature may be neurogenic claudication which is the onset and worsening of pain, weakness, numbness, tingling, heaviness, or fatigue sensation in the hips, buttocks, and lower limbs that is exacerbated with standing and walking, and improved with sitting or leaning forward on an object such as a shopping cart or walker

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Watch for issues with insulin and drugs that trigger insulin release like sulfonylureas or glinides, which raise your risk of low blood sugar