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This is due to concerns that the peptides proliferative effects could accelerate disease progression

Due to the efficacy of GLP-1 upon blood glucose regulation, DPP-4i has gradually become a new anti-diabetic drug for the treatment of type 2 diabetes mellitus (T2DM)

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IGF-1 LR3 for direct anabolic effects: Some protocols add IGF-1 LR3 to capitalize on both the endogenous IGF-1 elevation from GHRP-6 and the exogenous IGF-1 from direct administration

Clinical trial data suggest that gastrointestinal adverse effects typically peak during dose escalation and diminish with continued therapy at stable doses