Heres where it actually hits
F., Masini, G., et al
Interestingly, in addition to proper supplementation support, another recommended treatment for cerebral folate deficiency is a dairy-free diet (something I advocate for in Hashimotos too), as mammalian milk is thought to contribute to folate receptor antibodies, and may block folate transport to the brain
However, people always concentrate their mind on the efficacy and the mechanism of permeation of the conjugates across BBB, but overlook the toxicity of the membrane-permeable peptide itself. Once we injected intravenously not very large amounts of gamma-aminobutyric acid-MPP (GABA-MPP) to the mice, to our great surprise, the mice died within seconds with seizure, whereas the GABA control mice well survived
Although adding genetic data on the host would undoubtedly make research more expensive and analysis more difficult, it represents a realistic and valuable direction for moving from purely associative discoveries to a more definitive insight into the biological causation of ME/CFS
And it turns out to be a fragment a small piece snipped off a much larger protein [3]
