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N Engl J Med (2016) 375(4):31122

Baseline and periodic measurement of vitamins A, D, E, and K may be warranted in patients with documented malabsorption

However, further research is necessary to elucidate the underlying molecular mechanisms and validate the efficacy of NAC in clinical settings

SS-31 (elamipretide) , a mitochondria-targeted peptide that stabilizes cardiolipin to support energy production, became the first FDA-approved mitochondrial therapeutic in 2025, though only for the rare Barth syndrome, with the brain rationale still mechanistic and no cognitive trials

doi: 10.1128/AAC.04005-14 181 QuJ.LesseA