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Because the arginate form maintains stability longer in circulation, it provides more consistent systemic exposure

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Over the past decade, many hypermobile EDS (hEDS) patients have tried prolotherapy, and while responses vary, a significant number report meaningful improvements

These factors, including lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-), and interleukin-1 beta (IL-1), may impede P-gp activity, activate the mitogen-activated protein kinase (MAPK) signaling pathway, and increase nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) expression in ECs

Toxicity from B12-derived cyanide has never been documented even with mega-dose supplementation