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This leads to an imbalance of incretin activity in these patients, resulting in impaired glycemic control due to a decrease of insulin and an increase in blood glucose

Despite its widespread use, metformins application in patients with reduced kidney function has been limited due to concerns about lactic acidosis

Matinas BioPharma Holdings (NYSE American: MTNB) shares plunged 68% from $1.93 to 62 cents Thursday after the company slashed its workforce 80% and began exploring strategic options that include potential sale of its lead pipeline candidate MAT2203, the Phase III-ready oral formulation of amphotericin B, and a wind down and dissolution of the company

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fact, combining treatments often gives the best results