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Research indicates that individuals with depression or anxiety are at increased risk of weight gain, whilst obesity itself can contribute to psychological distress, creating a complex bidirectional relationship that may necessitate treatment of both conditions concurrently

However, many trials lacked rigorous controls, and publication bias toward positive findings is likely

Accordingly, the dysregulation of this signalling pathway contributes to the development of obesity and the chronic inflammation and metabolic dysregulation in adipose tissue [56, 57]

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Barrier protection limits harmful substance leakage into circulation (leaky gut conditions, toxin exposure)

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